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Simultaneous invasive and noninvasive electrophysiological recording

May 9, 2024

Research on the potential benefits of integrating intracranial EEG and scalp MEG/EEG

A recent review by researchers including CNTR faculty Drs. Angelique Paulk and Rina Zelmann, highlights the potential of simultaneously recording from the brain using invasive intracranial EEG and non-invasive scalp EEG or MEG. The dual approach has potential to enhance the precision and accuracy of our current technologies. The review emphasizes the importance of data sharing and collaboration to realize the complete benefits of this novel approach.


Simultaneous noninvasive and invasive electrophysiological recordings provide a unique opportunity to achieve a comprehensive understanding of human brain activity, much like a Rosetta stone for human neuroscience. In this review we focus on the increasingly-used powerful combination of intracranial electroencephalography (iEEG) with scalp electroencephalography (EEG) or magnetoencephalography (MEG). We first provide practical insight on how to achieve these technically challenging recordings. We then provide examples from clinical research on how simultaneous recordings are advancing our understanding of epilepsy. This is followed by the illustration of how human neuroscience and methodological advances could benefit from these simultaneous recordings. We conclude with a call for open data sharing and collaboration, while ensuring neuroethical approaches and argue that only with a true collaborative approach the promises of simultaneous recordings will be fulfilled.

To read about this study, please follow this link. 

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